Understand inherited risk and early-onset clues
Price: HK$2,300
COGENESIS® AD focuses on genetic factors associated with Alzheimer’s disease, helping doctors review inherited risk and early-onset clues. The result adds context to clinical assessment but does not diagnose Alzheimer’s disease on its own.
What the test covers
The test covers six commonly related genes: APP, PSEN1, PSEN2, APOE, TREM2 and MAPT. APOE genotype may also provide information about Alzheimer’s disease risk and certain treatment-related risk considerations.
Samples may be saliva or blood. The report time is around 4 weeks, counted after the sample reaches the laboratory and meets testing requirements.
Who may consider it
This genetic test may be suitable for people under 65 with cognitive changes, individuals with a family history of early-onset Alzheimer’s disease, those who want to understand inherited risk, or patients whose doctor would like to clarify possible genetic factors.
How It Differs From P-TAU 217
| Item | COGENESIS® AD | P-TAU 217 |
|---|---|---|
| Testing focus | Assessment of inherited risk and early-onset Alzheimer’s disease related genetic clues. | A blood biomarker test that supports assessment of tau pathology associated with Alzheimer’s disease. |
| Key content | Covers six commonly related genes: APP, PSEN1, PSEN2, APOE, TREM2 and MAPT. APOE genotype can also be reviewed when appropriate. | Measures plasma phosphorylated tau 217 (p-Tau217). When clinically indicated, doctors may interpret it together with APOE or Aβ42/40 information. |
| Who may consider it | People under 65 with cognitive changes, a family history of early-onset Alzheimer’s disease, or concerns about inherited risk. | People with memory or cognitive symptoms who need supportive biomarker information for Alzheimer’s disease related pathology. |
| Sample type | Saliva or blood. | Blood. |
| Report time | Around 4 weeks. | Around 10 to 14 working days. |
| Interpretation | Results provide genetic risk information or possible clues; they are not a clinical diagnosis by themselves. | Results are usually presented against reference intervals and should be interpreted with symptoms, history, cognitive assessment, imaging or other tests. |
Medical Note
Genetic test results reflect inherited risk or possible clues. They do not mean a person has Alzheimer’s disease or will definitely develop it. Results should be interpreted by a doctor together with personal history, symptoms, cognitive assessment and other investigations.
Enquire or Book
If you or your family would like to understand inherited Alzheimer’s disease risk, contact Well Clinic to enquire about COGENESIS® AD testing.
Tel: +852 2633 5288
WhatsApp / WeChat: +852 5292 0089
Address: Unit B, 24/F, Lee Dong Building, 9 Li Yuen Street East, Central, Hong Kong